She also appeared in the adaptation of the graphic novel Sin City, co-directed by Robert Rodriguez and Frank Miller, portraying Gail, a prostitute-dominatrix.
The following year, she reprised her role as Gail in Sin City: A Dame to Kill For. Presidential Election Dawson endorsed US Green Party Presidential Candidate Jill Stein, saying she could not support either Donald Trump or Hillary Clinton, as she felt they were for the elites.
In 2015, she played Claire Temple in the TV series Daredevil, a role which she reprised in Jessica Jones and Luke Cage. and supports other charities such as environmental group Global Cool, the ONE Campaign, Operation USA, Oxfam, Amnesty International, Parents, Families and Friends of Lesbians and Gays, the International Rescue Committee, Voto Latino, In October 2008, Dawson became a spokeswoman for Trip Advisor.com's philanthropy program, More Than Footprints, Conservation International, Doctors Without Borders, National Geographic Society, The Nature Conservancy, and Save The Children.
Dawson also sits on the Board of Directors of Scenarios USA, which works to support a generation of reflective, outspoken, and confident youth through filmmaking and uses film to educate students through a variety of programs.
Due to the comedian’s tendency to pull pranks, many fans were initially skeptical about the validity of their relationship, which they then confirmed with more romantic photos.
In 2009, Dawson also voiced the character of Velvet Von Black in Rob Zombie's animated feature, The Haunted World of El Superbeasto.